pu 1 inhibitor db1976 Search Results


pu 1 inhibitor db1976  (MedChemExpress)
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MedChemExpress pu 1 inhibitor db1976
A Schematic diagram of the experimental study design for scATAC-seq of lung tissues from wide-type HDM sensitized mice. B Uniform manifold approximation and projection (UMAP) plots of sorted viable CD45 + Lin ⁻ ICOS + ST2 + cells from HDM-sensitized mice at day 45 and day 47. Each dot represents a single cell, with different ILC2 subsets shown in different colors. C Alteration of chromatin accessibility in the ILC2_c02 subset at day 47 versus day 45. The Y axis presents the log2 fold change of gene activity at day 47 versus day 45 and in library 2, while the X axis shows the log2 fold change in library 1. D Transcription factor binding motifs significantly enriched in the ILC2_c02 subset at day 47 versus day 45. P- values were calculated by a right-tailed hypergeometric test. E DNA accessibility tracing of the Tlr4 and Il1rl1 of different ILC2 subsets. Shaded boxes delineate increased chromatin accessibility. F Predicted motifs within Tlr4 promoter. G Motif footprinting trace showing binding activities of transcription factor JunB, <t>Fos,</t> <t>PU.1</t> and MafK.
Pu 1 Inhibitor Db1976, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Schematic diagram of the experimental study design for scATAC-seq of lung tissues from wide-type HDM sensitized mice. B Uniform manifold approximation and projection (UMAP) plots of sorted viable CD45 + Lin ⁻ ICOS + ST2 + cells from HDM-sensitized mice at day 45 and day 47. Each dot represents a single cell, with different ILC2 subsets shown in different colors. C Alteration of chromatin accessibility in the ILC2_c02 subset at day 47 versus day 45. The Y axis presents the log2 fold change of gene activity at day 47 versus day 45 and in library 2, while the X axis shows the log2 fold change in library 1. D Transcription factor binding motifs significantly enriched in the ILC2_c02 subset at day 47 versus day 45. P- values were calculated by a right-tailed hypergeometric test. E DNA accessibility tracing of the Tlr4 and Il1rl1 of different ILC2 subsets. Shaded boxes delineate increased chromatin accessibility. F Predicted motifs within Tlr4 promoter. G Motif footprinting trace showing binding activities of transcription factor JunB, Fos, PU.1 and MafK.

Journal: Nature Communications

Article Title: TLR4 + group 2 innate lymphoid cells contribute to persistent type 2 immunity in airway diseases

doi: 10.1038/s41467-025-62532-0

Figure Lengend Snippet: A Schematic diagram of the experimental study design for scATAC-seq of lung tissues from wide-type HDM sensitized mice. B Uniform manifold approximation and projection (UMAP) plots of sorted viable CD45 + Lin ⁻ ICOS + ST2 + cells from HDM-sensitized mice at day 45 and day 47. Each dot represents a single cell, with different ILC2 subsets shown in different colors. C Alteration of chromatin accessibility in the ILC2_c02 subset at day 47 versus day 45. The Y axis presents the log2 fold change of gene activity at day 47 versus day 45 and in library 2, while the X axis shows the log2 fold change in library 1. D Transcription factor binding motifs significantly enriched in the ILC2_c02 subset at day 47 versus day 45. P- values were calculated by a right-tailed hypergeometric test. E DNA accessibility tracing of the Tlr4 and Il1rl1 of different ILC2 subsets. Shaded boxes delineate increased chromatin accessibility. F Predicted motifs within Tlr4 promoter. G Motif footprinting trace showing binding activities of transcription factor JunB, Fos, PU.1 and MafK.

Article Snippet: To confirm the role of transcriptional factor in induction of TLR4 on ILC2s, the ILC2s were pre-treated with the transcription factor c-Fos / AP-1 inhibitor T-5224 (20 μM, MCE) and the PU.1 inhibitor DB1976 (100 nM, MCE) for 1 h prior to stimulation.

Techniques: Activity Assay, Binding Assay, Footprinting